Susceptibility genes for complex epilepsy.

@article{Mulley2005SusceptibilityGF,
  title={Susceptibility genes for complex epilepsy.},
  author={John Charles Mulley and Ingrid E. Scheffer and Louise A. Harkin and Samuel F. Berkovic and Leanne Michelle Dibbens},
  journal={Human molecular genetics},
  year={2005},
  volume={14 Spec No. 2},
  pages={
          R243-9
        }
}
Common idiopathic epilepsies are, clinically and genetically, a heterogeneous group of complex seizure disorders. Seizures arise from periodic neuronal hyperexcitability of unknown cause. The genetic component is mostly polygenic, where each susceptibility gene in any given individual is likely to represent a small component of the total heritability. Two susceptibility genes have been so far identified, where genetic variation is associated with experimentally demonstrated changes in ion… CONTINUE READING

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