Susceptibility and outcome in MS: associations with polymorphisms in pigmentation-related genes.

@article{Partridge2004SusceptibilityAO,
  title={Susceptibility and outcome in MS: associations with polymorphisms in pigmentation-related genes.},
  author={Jeff Partridge and S. J. M. Weatherby and J A Woolmore and D J Highland and Anthony A Fryer and Cameron A Mann and Michael Boggild and William E. R. Ollier and Richard C. Strange and Clive Paul Hawkins},
  journal={Neurology},
  year={2004},
  volume={62 12},
  pages={2323-5}
}
Multiple sclerosis (MS) risk is determined by environment and genes. The authors investigated in 419 cases and 422 controls if polymorphism in the vitamin D receptor (VDR), melanocortin-1 receptor (MC1R), and tyrosinase (TYR) genes is linked with MS risk and outcome. VDR ff was associated with reduced (odds ratio [OR] = 0.59) and MC1R His294-encoding alleles with increased (OR = 2.21) risk. MC1R Glu84/Glu84 was linked with disability (OR = 5.65). These preliminary data suggest a role for these… CONTINUE READING

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