Susceptibility alleles for testicular germ cell tumour: a review.

  title={Susceptibility alleles for testicular germ cell tumour: a review.},
  author={Elizabeth A. Rapley},
  journal={International journal of andrology},
  volume={30 4},
          242-50; discussion 250
Family history is among the strongest and most consistent of the risk factors for testicular germ cell tumour (TGCT). Brothers of affected cases have an 8- to10-fold relative risk and fathers/sons have a risk between four and sixfold. The familial relative risk of TGCT is higher than for most other cancer types, which rarely exceeds four. The high relative risk suggests that inherited susceptibility to TGCT may account for a substantial fraction of TGCT cases. The search for TGCT susceptibility… CONTINUE READING