Susceptibility alleles for aberrant B-1 cell proliferation involved in spontaneously occurring B-cell chronic lymphocytic leukemia in a model of New Zealand white mice.

@article{Hamano1998SusceptibilityAF,
  title={Susceptibility alleles for aberrant B-1 cell proliferation involved in spontaneously occurring B-cell chronic lymphocytic leukemia in a model of New Zealand white mice.},
  author={Yasuharu Hamano and S. Hirose and A. Ida and Masaaki Abe and Danqing Zhang and Sanki Kodera and Yi Jiang and Junsuke Shirai and Yutaka Miura and Hiroyuki Nishimura and Toshikazu Shirai},
  journal={Blood},
  year={1998},
  volume={92 10},
  pages={3772-9}
}
B-cell chronic lymphocytic leukemia (B-CLL) and autoimmune disease are a related event, and genetic factors are linked to both diseases. As B-CLL is mainly of B-1 cell type that participates in autoantibody production, genetically-determined regulatory abnormalities in proliferation and/or differentiation of B-1 cells may determine their fate. We earlier found that, in H-2-congenic (NZB x NZW) F1 mice, while H-2(d/z) heterozygosity predisposes to autoimmune disease, H-2(z/z) homozygosity… CONTINUE READING

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