Susceptibilities of zidovudine-susceptible and -resistant human immunodeficiency virus isolates to antiviral agents determined by using a quantitative plaque reduction assay.

@article{Larder1990SusceptibilitiesOZ,
  title={Susceptibilities of zidovudine-susceptible and -resistant human immunodeficiency virus isolates to antiviral agents determined by using a quantitative plaque reduction assay.},
  author={Brendan Larder and Bruce Chesebro and Douglas D. Richman},
  journal={Antimicrobial agents and chemotherapy},
  year={1990},
  volume={34 3},
  pages={
          436-41
        }
}
Conventional assays based on infection of T-cell lymphoblastoid lines with tissue culture-adapted strains of human immunodeficiency virus (HIV) are well established and have been used successfully to discover potent inhibitors of HIV replication. In this report we show that such assays are not easily applied to testing the susceptibilities of clinical HIV isolates to inhibitors because of differences in replication rates and cytotoxicity, thus demonstrating that conventional HIV assays should… CONTINUE READING
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