Surviving the breakup: the DNA damage checkpoint.

@article{Harrison2006SurvivingTB,
  title={Surviving the breakup: the DNA damage checkpoint.},
  author={Jacob C. Harrison and James E. Haber},
  journal={Annual review of genetics},
  year={2006},
  volume={40},
  pages={
          209-35
        }
}
In response to even a single chromosomal double-strand DNA break, cells enact the DNA damage checkpoint. This checkpoint triggers cell cycle arrest, providing time for the cell to repair damaged chromosomes before entering mitosis. This mechanism helps prevent the segregation of damaged or mutated chromosomes and thus promotes genomic stability. Recent work has elucidated the molecular mechanisms underlying several critical steps in checkpoint activation, notably the recruitment of the upstream… 
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