Surviving metabolic stress: of mice (squirrels) and men.

Abstract

Understanding how cancer cells survive harsh environmental conditions may be fundamental to eradicating malignancies proven to be impervious to treatment. Nutrient and growth factor deprivation, hypoxia, and low pH create metabolic demands that require cellular adaptations to sustain energy levels. Protein synthesis is one of the most notable consumers of… (More)
DOI: 10.1158/2159-8290.CD-14-0114

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