Surviving life-threatening MDMA (3,4-methylenedioxymethamphetamine, ecstasy) toxicity caused by ritonavir (RTV)

@article{Papaseit2012SurvivingLM,
  title={Surviving life-threatening MDMA (3,4-methylenedioxymethamphetamine, ecstasy) toxicity caused by ritonavir (RTV)},
  author={E. Papaseit and A. V{\'a}zquez and C. P{\'e}rez-Ma{\~n}{\'a} and M. Pujadas and R. de la Torre and M. Farr{\'e} and J. Nolla},
  journal={Intensive Care Medicine},
  year={2012},
  volume={38},
  pages={1239-1240}
}
  • E. Papaseit, A. Vázquez, +4 authors J. Nolla
  • Published 2012
  • Medicine
  • Intensive Care Medicine
  • Dear Editor, Ritonavir (RTV) and MDMA (3,4methylenedioxymethamphetamine, ecstasy) are both substrates and/or potent inhibitors of the cytochrome P450 isoenzyme CYP2D6. Because of the potentially high toxicity of MDMA, the concomitant use of MDMA with any dose of RTV is contraindicated [1]. We report the first case of a subject treated chronically with RTV surviving a lifethreatening MDMA intoxication. A 23-year-old Caucasian HIVpositive man treated with RTV 100 mg/day, atazanavir 300 mg/day… CONTINUE READING
    14 Citations
    MDMA interactions with pharmaceuticals and drugs of abuse
    MDMA, methamphetamine, and CYP2D6 pharmacogenetics: what is clinically relevant?
    • 60
    • PDF
    How MDMA's Pharmacology and Pharmacokinetics Drive Desired Effects and Harms
    • 13
    Key interindividual determinants in MDMA pharmacodynamics
    • 6
    Cytotoxic effects of amphetamine mixtures in primary hepatocytes are severely aggravated under hyperthermic conditions.
    • 22
    nteracciones graves o potencialmente letales entre antirretrovirales otros medicamentos
    • PDF

    References

    SHOWING 1-6 OF 6 REFERENCES
    Sex Differences in 3,4-Methylenedioxymethamphetamine (MDMA; Ecstasy)-Induced Cytochrome P450 2D6 Inhibition in Humans
    • 24
    The Consequences of 3,4-Methylenedioxymethamphetamine Induced CYP2D6 Inhibition in Humans
    • 50
    • PDF
    Non-linear pharmacokinetics of MDMA ('ecstasy') in humans.
    • 339
    • PDF
    Life-threatening interactions between HIV-1 protease inhibitors and the illicit drugs MDMA and gamma-hydroxybutyrate.
    • 114
    • Highly Influential
    • PDF
    Fatal interaction between ritonavir and MDMA
    • 130
    • Highly Influential