Surviving life-threatening MDMA (3,4-methylenedioxymethamphetamine, ecstasy) toxicity caused by ritonavir (RTV)

  title={Surviving life-threatening MDMA (3,4-methylenedioxymethamphetamine, ecstasy) toxicity caused by ritonavir (RTV)},
  author={E. Papaseit and A. V{\'a}zquez and C. P{\'e}rez-Ma{\~n}{\'a} and M. Pujadas and R. de la Torre and M. Farr{\'e} and J. Nolla},
  journal={Intensive Care Medicine},
  • E. Papaseit, A. Vázquez, +4 authors J. Nolla
  • Published 2012
  • Medicine
  • Intensive Care Medicine
  • Dear Editor, Ritonavir (RTV) and MDMA (3,4methylenedioxymethamphetamine, ecstasy) are both substrates and/or potent inhibitors of the cytochrome P450 isoenzyme CYP2D6. Because of the potentially high toxicity of MDMA, the concomitant use of MDMA with any dose of RTV is contraindicated [1]. We report the first case of a subject treated chronically with RTV surviving a lifethreatening MDMA intoxication. A 23-year-old Caucasian HIVpositive man treated with RTV 100 mg/day, atazanavir 300 mg/day… CONTINUE READING
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