Surviving ischemia: adaptive responses mediated by hypoxia-inducible factor 1.

@article{Semenza2000SurvivingIA,
  title={Surviving ischemia: adaptive responses mediated by hypoxia-inducible factor 1.},
  author={Gregg L Semenza},
  journal={The Journal of clinical investigation},
  year={2000},
  volume={106 7},
  pages={
          809-12
        }
}
While the other Perspectives in this series provide readers with state-of-the-art overviews of responses to ischemia on an organ-by-organ basis, I focus here on a single transcription factor, hypoxia-inducible factor 1 (HIF-1), and its role in the physiologic responses to hypoxia and ischemia. Whether in the brain, heart, kidneys, lungs, or muscle, HIF-1 is essential for ischemiainduced angiogenesis, as described by Isner (this Perspective series, ref. 1), and it may also be a critical mediator… CONTINUE READING

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Hypoxia-inducible factor 1 (HIF-1) role in hypoxia-induced ischemic tolerance in neonatal rat brain

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