Surviving blood loss without fluid resuscitation.

  title={Surviving blood loss without fluid resuscitation.},
  author={Christian C. Shults and Elizabeth A. Sailhamer and Yongqing Li and Baoling Liu and Malek Tabbara and Muhammad Umar Butt and Fahad Shuja and Marc A Demoya and George C. Velmahos and Hasan B Alam},
  journal={The Journal of trauma},
  volume={64 3},
          629-38; discussion 638-40
BACKGROUND Patients with massive blood loss often die before delivery of definitive care, especially in austere environments. Strategies that can maintain life during evacuation and transport to higher levels of care may be lifesaving. We have previously shown that administration of histone deacetylase inhibitors (HDACI) enhance gene transcription through specific modifications of DNA-associated histone proteins. Furthermore, it protects against organ damage when given before hemorrhage. The… CONTINUE READING
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