Surviving at a Distance: Organ-Specific Metastasis.

  title={Surviving at a Distance: Organ-Specific Metastasis.},
  author={Anna Christina Obenauf and Joan Massagu{\'e}},
  journal={Trends in cancer},
  volume={1 1},
The clinical manifestation of metastasis in a vital organ is the final stage of cancer progression and the main culprit of cancer-related mortality. Once established, metastasis is devastating, but only a small proportion of the cancer cells that leave a tumor succeed at infiltrating, surviving, and ultimately overtaking a distant organ. The bottlenecks that challenge cancer cells in newly invaded microenvironments are organ-specific and consequently demand distinct mechanisms for metastatic… CONTINUE READING
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