Survivin signaling in clinical oncology: a multifaceted dragon.

  title={Survivin signaling in clinical oncology: a multifaceted dragon.},
  author={J. R. Kanwar and Sishir K Kamalapuram and Rupinder Kaur Kanwar},
  journal={Medicinal research reviews},
  volume={33 4},
Survivin is an inhibitor of apoptosis protein (IAP) family member preferentially expressed in a myriad of clinical cancers. The complex functional mechanism and regulatory roles of survivin in cell division and cell death has hindered current therapeutic regimes from decoding its diagnostic, prognostic, and therapeutic significance in the area of translational oncology. Pharmacological modulation of survivin was tagged with its evolving functional complexity associated with various cell… CONTINUE READING
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