Survivin role in pulmonary arterial hypertension

  title={Survivin role in pulmonary arterial hypertension},
  author={Manuel Jo{\~a}o Ferreira-Pinto and Ana Filipa Silva and Rita Nogueira-Ferreira and Ana Isabel Padr{\~a}o and Daniel Moreira-Gonçalves and Fl{\'a}via Aceituno Carneiro and Raquel Jo{\~a}o Magro Costa and Laura Ribeiro and Adelino F Leite-Moreira and Tiago Henriques-Coelho},
Purpose: Survivin is an inhibitor of apoptosis expressed in the vascular lesions of pulmonary arterial hypertension (PAH) and is also involved in myocardial remodeling during left heart failure. The current work aims at: investigating right ventricular (RV) expression of survivin and smac/DIABLO (an inhibitor of survivin) throughout the hemodynamic and morphometric progression of monocrotaline (MCT)-induced PAH; and characterizing the effects of the survivin antagonist terameprocol in pulmonary… CONTINUE READING

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