Survivin reads phosphorylated histone H3 threonine 3 to activate the mitotic kinase Aurora B.

@article{Kelly2010SurvivinRP,
  title={Survivin reads phosphorylated histone H3 threonine 3 to activate the mitotic kinase Aurora B.},
  author={Alexander E Kelly and Cristina Ghenoiu and John Zhao Xue and Christian Zierhut and Hiroshi Kimura and Hironori Funabiki},
  journal={Science},
  year={2010},
  volume={330 6001},
  pages={
          235-9
        }
}
A hallmark of mitosis is the appearance of high levels of histone phosphorylation, yet the roles of these modifications remain largely unknown. Here, we demonstrate that histone H3 phosphorylated at threonine 3 is directly recognized by an evolutionarily conserved binding pocket in the BIR domain of Survivin, which is a member of the chromosomal passenger complex (CPC). This binding mediates recruitment of the CPC to chromosomes and the resulting activation of its kinase subunit Aurora B… CONTINUE READING

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