Survivin promoter polymorphism and cervical carcinogenesis.


BACKGROUND Survivin, a novel member of the inhibitor of apoptosis family, plays an important role in cell cycle regulation. A common polymorphism at the survivin gene promoter (G/C at position 31) was shown to be correlated with survivin gene expression in cancer cell lines. AIM To investigate whether this polymorphism could be involved in the development… (More)