Survivin is a therapeutic target in Merkel cell carcinoma.

  title={Survivin is a therapeutic target in Merkel cell carcinoma.},
  author={Reety Arora and Masahiro Shuda and Anna Guastafierro and Huichen Feng and Tuna Toptan and Yanis Tolstov and Daniel P Normolle and Laura L. Vollmer and Andreas Vogt and Alexander S. D{\"o}mling and Jeffrey L Brodsky and Yuan - Chia Chang Yeun - Chung Chang Chin - Chen Chang and Patrick S Moore},
  journal={Science translational medicine},
  volume={4 133},
Merkel cell polyomavirus (MCV) causes ~80% of primary and metastatic Merkel cell carcinomas (MCCs). By comparing digital transcriptome subtraction deep-sequencing profiles, we found that transcripts of the cellular survivin oncoprotein [BIRC5a (baculoviral inhibitor of apoptosis repeat-containing 5)] were up-regulated sevenfold in virus-positive compared to virus-negative MCC tumors. Knockdown of MCV large T antigen in MCV-positive MCC cell lines decreased survivin mRNA and protein expression… CONTINUE READING
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Sasamata, YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts

  • T. Nakahara, M. Takeuchi, +7 authors M. M. Kudoh
  • Cancer Res
  • 2007
Highly Influential
4 Excerpts

A virus-induced human cancer

  • Y. Chang, P. S. Moore, Merkel cell carcinoma
  • Annu. Rev. Pathol. 7, 123–144
  • 2012
1 Excerpt

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