Survivin expression predicts poorer prognosis in anaplastic large-cell lymphoma.

  title={Survivin expression predicts poorer prognosis in anaplastic large-cell lymphoma.},
  author={Ellen J. Schlette and L Jeffrey Medeiros and Andre Goy and Raymond Lai and George Z. Rassidakis},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  volume={22 9},
PURPOSE Survivin, a member of the inhibitor of apoptosis (IAP) family, is not detected in normal adult tissues but is overexpressed in various cancers, including some types of lymphoma. The frequency and prognostic significance of survivin expression in anaplastic large-cell lymphoma (ALCL) is unknown. MATERIALS AND METHODS We assessed for survivin expression in 62 ALCL tumors (30 anaplastic lymphoma kinase [ALK]-positive and 32 ALK-negative) obtained before doxorubicin-based chemotherapy… CONTINUE READING
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