Survivin expression in the progression of chronic myeloid leukemia: a sequential study in 16 patients.

@article{HernndezBoluda2005SurvivinEI,
  title={Survivin expression in the progression of chronic myeloid leukemia: a sequential study in 16 patients.},
  author={Juan-Carlos Hern{\'a}ndez-Boluda and Beatriz Bellosillo and M B Vela and Dolors Colomer and Alberto {\'A}lvarez-Larr{\'a}n and Francisco Cervantes},
  journal={Leukemia & lymphoma},
  year={2005},
  volume={46 5},
  pages={717-22}
}
An increase in the proliferation and resistance to apoptosis of leukemic cells has been found in chronic myeloid leukemia (CML) as the disease evolves from the chronic phase to blast crisis (BC). To contribute to a better knowledge of the molecular mechanisms involved in such biological abnormality, the expression of the survivin gene was studied by quantitative real-time polymerase chain reaction (PCR) in the chronic phase of CML and at BC in 16 patients in whom sequential RNA samples from the… CONTINUE READING