Survivin expression in in situ and invasive breast cancer relates to COX-2 expression and DCIS recurrence

@article{Barnes2006SurvivinEI,
  title={Survivin expression in in situ and invasive breast cancer relates to COX-2 expression and DCIS recurrence},
  author={Nicola L. P. Barnes and Philippa Haywood and Pamela J. Flint and W. Fiona Knox and Nigel J. Bundred},
  journal={British Journal of Cancer},
  year={2006},
  volume={94},
  pages={253 - 258}
}
In lung cancer cyclooxygenase-2 (COX-2) expression has been reported to stabilise survivin, an inhibitor of apoptosis (IAP) which prevents cell death by blocking activated caspases. COX-2 expression limits the ubiquitination of survivin, protecting it from degradation. To determine if COX-2 expression in breast cancer showed an association with survivin expression, we assessed the levels of each protein in ductal carcinoma in situ (DCIS) and invasive breast cancer (IBC); relating expression… CONTINUE READING
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Cyclooxygenase-2 inhibition induces apoptosis via PKB pathway and reduces lymphangiogenesis

  • NLP Barnes, F Warnberg, G Farnie, W Jiang, E Anderson, NJ Bundred
  • Breast Cancer Res Treat
  • 2004
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