Survivin expression in hepatocellular carcinoma: correlation with proliferation, prognostic parameters, and outcome

@article{Fields2004SurvivinEI,
  title={Survivin expression in hepatocellular carcinoma: correlation with proliferation, prognostic parameters, and outcome},
  author={Angela C Fields and George Cotsonis and Debbie Sexton and Robert A Santoianni and Cynthia K Cohen},
  journal={Modern Pathology},
  year={2004},
  volume={17},
  pages={1378-1385}
}
Survivin is a novel inhibitor of apoptosis. It is detected in fetal and neoplastic adult tissue, but not in normal tissues. Several recent studies have shown that survivin not only inhibits apoptosis, but also accelerates cancer cell proliferative activity. Expression of the protein may be of prognostic significance and therapeutic relevance in many cancers. We investigated survivin expression in hepatocellular carcinoma, correlating results with proliferation (MIB-1), prognostic factors, and… CONTINUE READING