Survivin-directed RNA interference cocktail is a potent suppressor of tumour growth in vivo.

@article{Caldas2006SurvivindirectedRI,
  title={Survivin-directed RNA interference cocktail is a potent suppressor of tumour growth in vivo.},
  author={Hugo Caldas and Michael P. Holloway and Brett Hall and Stephen J. Qualman and Rachel A. Altura},
  journal={Journal of medical genetics},
  year={2006},
  volume={43 2},
  pages={119-28}
}
BACKGROUND Survivin is proposed to play a central role in the progression and resistance to therapy of diverse tumour types. High levels of this molecule in tumour cells also correlate with loss of the TP53 tumour suppressor gene, suggesting a molecular connection between TP53 loss and transcriptional induction of Survivin. Patients with TP53 germline mutations, such as those with Li-Fraumeni syndrome, are particularly susceptible to sarcomas, including rhabdomyosarcomas. Our study aimed to… CONTINUE READING

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