Survivin as a target for new anticancer interventions.

  title={Survivin as a target for new anticancer interventions.},
  author={Nadia Zaffaroni and Marzia Pennati and Maria Grazia Daidone},
  journal={Journal of cellular and molecular medicine},
  volume={9 2},
Survivin is a member of the inhibitor of apoptosis protein (IAP) family, that has been implicated in both control of cell division and inhibition of apoptosis. Specifically, its anti-apoptotic function seems to be related to the ability to directly or indirectly inhibit caspases. Survivin is selectively expressed in the most common human neoplasms and appears to be involved in tumor cell resistance to some anticancer agents and ionizing radiation. On the basis of these findings survivin has… CONTINUE READING