Survivin and laryngeal carcinoma prognosis: nuclear localization and expression of splice variants

@article{Marioni2012SurvivinAL,
  title={Survivin and laryngeal carcinoma prognosis: nuclear localization and expression of splice variants},
  author={Gino Marioni and Marco Agostini and Chiara Bedin and Stella Blandamura and Edoardo Stellini and Giovanni Favero and Marco Lionello and Luciano Giacomelli and S. Burti and Edoardo D’Angelo and Donato Nitti and Alberto Staffieri and Cosimo de Filippis},
  journal={Histopathology},
  year={2012},
  volume={61}
}
Marioni G, Agostini M, Bedin C, Blandamura S, Stellini E, Favero G, Lionello M, Giacomelli L, Burti S, D’Angelo E, Nitti D, Staffieri A & De Filippis C 
(2012) Histopathology 61, 247–256 
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22 Citations
Background Citations
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22 Citations

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Citation Type

Adenoid cystic carcinoma of the lacrimal gland: role of nuclear survivin (BIRC5) as a prognostic marker
This study aimed to evaluate the expression of nuclear survivin in adenoid cystic carcinoma (ACC) of the lacrimal gland and to determine if this expression is associated with histopathological…
Expression Profile of Survivin and p16 in Laryngeal Squamous Cell Carcinoma: Contribution of Tunisian Patients
TLDR
The data indicated that, in Tunisian laryngeal squamous cell carcinoma, survivin expression is associated with unfavorable outcomes and represents a predictor marker of recurrence and chemoresistance, however, p16 expression has no prognosis value.
Survivin and cortactin expression in sinonasal schneiderian (inverted) papilloma and associated carcinoma
TLDR
Prospective, multi-institutional prognostic studies are needed to confirm the role of survivin in IP malignant transformation, as nuclear survivin expression was significantly higher in SCCs than in IPs.
Correlation between Survivin expression and laryngeal carcinoma: A meta-analysis
  • Juan Geng, Y. Lei, Sheng-Guang Pei
  • Medicine
    Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban
  • 2017
TLDR
Survivin may play an important role in the occurrence and development of laryngeal carcinoma, and its high expression is related to the poor prognosis of patients with larynGEal cancer.
Expression of maspin tumor suppressor and mTOR in laryngeal carcinoma.
An Argument to Examine Exosomal Survivin Splice Variant Expression and Patient Survival in Pancreatic Cancer
TLDR
Although FOLFIRINOX has been proven to provide better outcomes than single drug therapies, its ability to induce a resectable conversion was only 20% of all locally advanced PCa patients who were treated, suggesting that there is still need for further experimental therapy investigation for PCa.
Nuclear survivin expression correlates with endoglin-assessed microvascularisation in laryngeal carcinoma
TLDR
Survivin-targeting strategies to enhance tumour cell response to apoptosis and inhibit tumour growth should receive more attention with a view to developing agents for use in multimodality advanced LSCC treatment, or combined with conventional chemotherapy.
Immunohistochemical study on survivin in sinonasal tumors and its relationship with the immunoexpression of Ki67 and Bcl-2.
TLDR
The findings suggest that survivin, Ki67 and Bcl-2 may be involved in sinonasal tumorigenesis.
miR-19a and SOCS-1 expression in the differential diagnosis of laryngeal (glottic) verrucous squamous cell carcinoma
TLDR
Preliminary outcomes suggest the utility of miR-19a in the challenging differential diagnosis of laryngeal VSCC and the former's potential role in differentiating between glottic VSCC, conventional SCC and hyperplastic lesions.
Correlation between Survivin expression and laryngeal carcinoma: A meta-analysis
TLDR
Substantial evidence is shown that Survivin may play an important role in the occurrence and development of laryngeal carcinoma, and its high expression is related to the poor prognosis of patients with larynGEal cancer.
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References

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Aurora B kinase expression in laryngeal squamous cell carcinoma and its prognostic implications
TLDR
Aurora B kinase expression in laryngeal squamous cell carcinoma and its prognostic implications is studied.
Survivin expression is a negative prognostic marker in laryngeal squamous cell carcinoma and is associated with p53 accumulation
TLDR
To investigate survivin expression in laryngeal squamous cell carcinoma (LSCC), its prognostic significance and relation to p53 status, and to suggest that wild‐type p53 represses survivinexpression.
Anti-apoptosis gene, survivin, and prognosis of neuroblastoma
Survivin gene-expression and splicing isoforms in oral squamous cell carcinoma
TLDR
The findings suggest that survivin isoforms deregulation may have significant implications in tumor aggressiveness and prognosis.
Dynamic survivin in head and neck cancer: Molecular mechanism and therapeutic potential
TLDR
Current understanding of the molecular mechanisms regulating survivin's intracellular localization is focused on and its potential prognostic and therapeutic relevance for head and neck cancer is discussed.
Survivin multifaceted activity in head and neck carcinoma: Current evidence and future therapeutic challenges
TLDR
Multiple evidence indicates that, in HNSCC cell lines, survivin inhibition by gene therapy and by small molecule inhibitors significantly increases the anti-tumour activity of several cytotoxic and other targeted therapies.
Survivin expression in laryngeal squamous cell carcinomas and its prognostic implications.
TLDR
Findings indicate that survivin expression is associated with unfavorable clinicopathological parameters and represents an independent marker for prognosis of LSCC.
Significance and relationship between DJ-1 gene and survivin gene expression in laryngeal squamous cell carcinoma
TLDR
A positive correlation between DJ-1 and survivin gene expression in laryngeal carcinoma was found and it was found thatDJ-1 may promote the carcinogenesis of larynGEal cells by up-regulating the survivIn gene expression.
Survivin study: An update of “What is the next wave?”
TLDR
The role of survivin, and its splice variants in the mitosis/cell cycle, apoptosis, tumorigenesis, chemoprevention, drug/radiation resistance, and cancer therapeutics is updated.
Cancer cells survive with survivin
TLDR
Findings suggest that survivin may be a promising molecular target against human malignancies and certain antitumor agents can reduce survivin expression.
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