Survivin and its prognostic significance in pediatric acute B-cell precursor lymphoblastic leukemia.

@article{Troeger2007SurvivinAI,
  title={Survivin and its prognostic significance in pediatric acute B-cell precursor lymphoblastic leukemia.},
  author={Anja Troeger and Meinolf Siepermann and Gabriele M Escherich and Roland Meisel and Reinhardt Willers and Sonja Gudowius and Thomas Moritz and Hans J{\"u}rgen Laws and Helmut Hanenberg and Ulrich Goebel and Gritta E. Janka-Schaub and Csaba Mahotka and Dagmar Dilloo},
  journal={Haematologica},
  year={2007},
  volume={92 8},
  pages={1043-50}
}
BACKGROUND AND OBJECTIVES Impaired apoptosis, mediated by members of the inhibitor of apoptosis proteins (IAP) family such as survivin, is thought to contribute to leukemic cell survival. In contrast to low expression of survivin in normal differentiated adult tissues, very high levels of survivin have been described in a number of different tumors. Overexpression of survivin was found to correlate with poor prognosis in a variety of cancers including hematologic malignancies. To date, however… CONTINUE READING

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The expression of 70 apoptosis genes in relation to lineage, genetic subtype, cellular drug resistance, and outcome in childhood acute lymphoblastic leukemia

  • A Holleman, ML den Boer, RX de Menezes, MH Cheok, C Cheng, KM Kazemier
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