Survivin: a target from brain cancer to neurodegenerative disease.

  title={Survivin: a target from brain cancer to neurodegenerative disease.},
  author={Sara Baratchi and Rupinder Kaur Kanwar and J. R. Kanwar},
  journal={Critical reviews in biochemistry and molecular biology},
  volume={45 6},
Apoptosis is an important contributing factor during neuronal death in a variety of neurodegenerative disorders, including multiple sclerosis, Parkinson's disease and sciatic nerve injury. Whereas several clinical and preclinical studies have focused on the neuroprotective effects of caspase inhibitors, their clinical benefits are still unclear. Here, we discuss novel alternative strategies to protect neuronal cells from apoptotic death using members of the inhibitors of apoptosis (IAP) family… CONTINUE READING


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