Survival without brain damage after clinical death of 60–120 mins in dogs using suspended animation by profound hypothermia*

@article{Behringer2003SurvivalWB,
  title={Survival without brain damage after clinical death of 60–120 mins in dogs using suspended animation by profound hypothermia*},
  author={Wilhelm Behringer and Peter J Safar and Xianren Wu and Rainer Kentner and Ann Sypniewski Radovsky and Patrick M. Kochanek and C E Dixon and Samuel A. Tisherman},
  journal={Critical Care Medicine},
  year={2003},
  volume={31},
  pages={1523-1531}
}
ObjectivesThis study explored the limits of good outcome of brain and organism achievable after cardiac arrest (no blood flow) of 60–120 mins, with preservation (suspended animation) induced immediately after the start of exsanguination cardiac arrest. DesignProspective experimental comparison of three arrest times, without randomization. SettingUniversity research laboratory. SubjectsTwenty-seven custom-bred hunting dogs (17–25 kg). InterventionsDogs were exsanguinated over 5 mins to cardiac… Expand
Suspended animation can allow survival without brain damage after traumatic exsanguination cardiac arrest of 60 minutes in dogs.
TLDR
Rapid induction of profound hypothermic suspended animation can enable survival without brain damage after exsanguination cardiac arrest of 60 minutes even in the presence of trauma, although prolonged intensive care may be required. Expand
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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Novel Potentials for Emergency Hypothermia: Suspended Animation with Delayed Resuscitation from Exsanguination Cardiac Arrest
TLDR
Suspended animation with delayed resuscitation represents a revolutionary approach to resuscitation of the trauma victim with otherwise lethal exsanguination cardiac arrest and suggest additional benefit from the combination of antioxidants with hypothermia, and challenge the previously posed limits of hypothermic protection and preservation of the brain. Expand
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TLDR
A single high-volume flush of cold saline into the abdominal aorta given 2 min after the onset of cardiac arrest rapidly induces moderate-to-deep cerebral hypothermia and can result in survival without functional or histologic brain damage, even after 30 min of no blood flow. Expand
Rapid induction of mild cerebral hypothermia by cold aortic flush achieves normal recovery in a dog outcome model with 20-minute exsanguination cardiac arrest.
TLDR
The same model with aortic arch flush of 24 degrees C results in survival with brain damage in all dogs, which makes it suitable for testing other (e.g., pharmacologic) preservation potentials. Expand
Adenosine by aortic flush fails to augment the brain preservation effect of mild hypothermia during exsanguination cardiac arrest in dogs - an exploratory study.
TLDR
A dog model for exploring pharmacological strategies for the rapid induction by aortic arch flush of suspended animation (SA), i.e. preservation of cerebral viability for 15 min or longer, and hypothesized that the addition of adenosine would achieve recovery with no histologic damage. Expand
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OBJECTIVE We hypothesize that during severe normothermic hemorrhagic shock (HS), induction of profound hypothermic circulatory arrest (PHCA) of 60 minutes to allow repair of otherwise lethal injuriesExpand
Hypothermic aortic arch flush for preservation during exsanguination cardiac arrest of 15 minutes in dogs.
TLDR
At the start of 15 minutes of exsanguination cardiac arrest in dogs, hypothermic aortic arch flush allows resuscitation to survival with normal neurologic function and histologically almost clean brains. Expand
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TLDR
It is concluded that neither thiopental alone nor Thiopental plus phenytoin by flush, with or without additional intravenous infusion, can consistently provide 'clinically significant' cerebral preservation for 20 min no-flow. Expand
Antioxidant Tempol Enhances Hypothermic Cerebral Preservation during Prolonged Cardiac Arrest in Dogs
  • W. Behringer, P. Safar, +9 authors S. Tisherman
  • Medicine
  • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2002
TLDR
The authors conclude that when added to aortic saline flush at the start of prolonged cardiac arrest, the antioxidant Tempol can enhance mild or moderate hypothermic cerebral preservation in terms of improved functional outcome. Expand
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TLDR
The results support the use of an initial bout of severe hypertension, but not theUse of delayed hemodilution in dogs after cardiac arrest, and total histopathologic damage scores were similar among the groups. Expand
Regional Prevalence and Distribution of Ischemic Neurons in Dog Brains 96 Hours After Cardiac Arrest of 0 to 20 Minutes
TLDR
The hypothesis that increases in the total prevalence of necrotic neurons better correspond to increasing arrest duration and better correlate with neurological deficit than do any individual regional scores is tested. Expand
Regional prevalence and distribution of ischemic neurons in dog brains 96 hours after cardiac arrest of 0 to 20 minutes.
TLDR
There were consistent increases in the mean prevalence of necrotic neurons with increased arrest duration in the hippocampal dentate gyrus and for cerebellar granule neurons and the caudate nucleus had the best correlation with clinical neurological deficit. Expand
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