Survival trees with time-dependent covariates: application to estimating changes in the incubation period of AIDS.

@article{Bacchetti1995SurvivalTW,
  title={Survival trees with time-dependent covariates: application to estimating changes in the incubation period of AIDS.},
  author={Peter Bacchetti and Mark R. Segal},
  journal={Lifetime data analysis},
  year={1995},
  volume={1 1},
  pages={35-47}
}
Tree-structured methods for exploratory data analysis have previously been extended to right-censored survival data. We further extend these methods to allow for truncation and time-dependent covariates. We apply the new methods to a data set on incubation times of acquired immunodeficiency syndrome (AIDS), using calendar time as a time-dependent covariate. Contrary to expectation, we find that rates of progression to AIDS appear to be faster after August 1989 than before.