Survival of myocardial infarction long-term evaluation (SMILE) study: rationale, design, organization, and outcome definitions.

@article{Ambrosioni1994SurvivalOM,
  title={Survival of myocardial infarction long-term evaluation (SMILE) study: rationale, design, organization, and outcome definitions.},
  author={Ettore Ambrosioni and Claudio Borghi and Bruno Magnani},
  journal={Controlled clinical trials},
  year={1994},
  volume={15 3},
  pages={201-10}
}
The rationale, design, organization, and outcome definitions of the Survival of Myocardial Infarction Long-term Evaluation (SMILE) study are described in detail. Recruitment of a total of 1500 patients (750 per treatment group) has been planned for this multicenter, double-masked, randomized, placebo-controlled trial investigating the effects of oral treatment with zofenopril calcium (7.5-30 mg twice a day) on the combined short-term total mortality and occurrence of severe refractory… CONTINUE READING