Survival of lethal poxvirus infection in mice depends on TLR9, and therapeutic vaccination provides protection.

@article{Samuelsson2008SurvivalOL,
  title={Survival of lethal poxvirus infection in mice depends on TLR9, and therapeutic vaccination provides protection.},
  author={Christofer Samuelsson and J{\"u}rgen Hausmann and Henning Lauterbach and Michaela Schmidt and Shizuo Akira and Hermann Wagner and Paul J. Chaplin and Mark Suter and Meredith O'keeffe and Hubertus Hochrein},
  journal={The Journal of clinical investigation},
  year={2008},
  volume={118 5},
  pages={1776-84}
}
Poxviruses such as the causative agent of smallpox have developed multiple strategies to suppress immune responses, including the suppression of DC activation. Since poxviruses are large DNA viruses, we hypothesized that their detection by DCs may involve the endosomal DNA recognition receptor TLR9. Indeed, we have shown here that DC recognition of… CONTINUE READING
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