Survival of human induced pluripotent stem cell-derived midbrain dopaminergic neurons in the brain of a primate model of Parkinson's disease.

@article{Kikuchi2011SurvivalOH,
  title={Survival of human induced pluripotent stem cell-derived midbrain dopaminergic neurons in the brain of a primate model of Parkinson's disease.},
  author={Tetsuhiro Kikuchi and Asuka Morizane and Daisuke Doi and Hirotaka Onoe and Takuya Hayashi and Toshiyuki Kawasaki and Hidemoto Saiki and Susumu Miyamoto and Jun Takahashi},
  journal={Journal of Parkinson's disease},
  year={2011},
  volume={1 4},
  pages={395-412}
}
Before induced pluripotent stem cells (iPSCs) can be used to treat neurologic diseases, human iPSC-derived neural cells must be analyzed in the primate brain. In fact, although mouse and human iPSCs have been used to generate dopaminergic (DA) neurons that are beneficial in rat models of Parkinson's disease (PD), human iPSC-derived neural progenitor cells (NPCs) have not been examined in primate brains. Here, we generated NPCs at different stages of predifferentiation using a feeder-free… CONTINUE READING