Survival of cancer cells is maintained by EGFR independent of its kinase activity.

@article{Weihua2008SurvivalOC,
  title={Survival of cancer cells is maintained by EGFR independent of its kinase activity.},
  author={Zhang Weihua and Rachel Z Tsan and Wei-Chien Huang and Qiuyu Wu and C-F. Chiu and Isaiah J. Fidler and Mien-Chie Hung},
  journal={Cancer cell},
  year={2008},
  volume={13 5},
  pages={
          385-93
        }
}
Expression of the epidermal growth factor receptor (EGFR), a receptor tyrosine kinase associated with cell proliferation and survival, is overactive in many tumors of epithelial origin. Blockade of the kinase activity of EGFR has been used for cancer therapy; however, by itself, it does not seem to reach maximum therapeutic efficacy. We report here that in human cancer cells, the function of kinase-independent EGFR is to prevent autophagic cell death by maintaining intracellular glucose level… CONTINUE READING

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