Survival of adult spiral ganglion neurons requires erbB receptor signaling in the inner ear.

@article{Stankovic2004SurvivalOA,
  title={Survival of adult spiral ganglion neurons requires erbB receptor signaling in the inner ear.},
  author={Konstantina M. Stankovic and Carlos Rio and Anping Xia and Mitsuru Sugawara and Joe C. Adams and M Charles Liberman and Gabriel Corfas},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2004},
  volume={24 40},
  pages={8651-61}
}
Degeneration of cochlear sensory neurons is an important cause of hearing loss, but the mechanisms that maintain the survival of adult cochlear sensory neurons are not clearly defined. We now provide evidence implicating the neuregulin (NRG)-erbB receptor signaling pathway in this process. We found that NRG1 is expressed by spiral ganglion neurons (SGNs), whereas erbB2 and erbB3 are expressed by supporting cells of the organ of Corti, suggesting that these molecules mediate interactions between… CONTINUE READING
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