Survival of acute myeloid leukemia cells requires PI3 kinase activation.

  title={Survival of acute myeloid leukemia cells requires PI3 kinase activation.},
  author={Qing Xu and Serge-Emile Simpson and Timothy J Scialla and Adam Bagg and Martin Carroll},
  volume={102 3},
The mechanisms that regulate the growth and survival of acute myeloid leukemia (AML) cells are largely unknown. We hypothesized that constitutive activation of phosphatidyl-inositide 3 kinase (PI3 kinase) could regulate survival in primary cells from patients with AML. Here we demonstrate that Akt, a critical substrate of PI3 kinase, is activated in AML blasts. In a short-term culture system, most AML patient samples showed a dose-dependent decrease in survival after incubation with the PI3… CONTINUE READING
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