Survival of HER2-Positive Breast Cancer Cells: Receptor Signaling to Apoptotic Control Centers.

Abstract

HER2 is overexpressed in a subset of breast cancers and controls an oncogenic signaling network that inhibits tumor cell death through the specific biochemical regulation of apoptotic pathways. In particular, the mitochondrial pathway for apoptosis is important for death induced by inhibitors of HER2. This review focuses on the connections between this… (More)
DOI: 10.1177/1947601913488598

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