Survival motor neuron protein facilitates assembly of stress granules.

@article{Hua2004SurvivalMN,
  title={Survival motor neuron protein facilitates assembly of stress granules.},
  author={Yimin Hua and Jian-hua Zhou},
  journal={FEBS letters},
  year={2004},
  volume={572 1-3},
  pages={69-74}
}
The survival motor neuron (SMN) protein forms cytoplasmic granules when overexpressed. We report here that SMN co-localizes with TIA-1/R and G3BP, protein assemblers of stress granules (SGs), and that SMN is co-immunoprecipitated with TIA-1/R, suggesting that SMN granules are SGs. Formation of SMN granules precedes accumulation of TIA-1/R, indicating that SMN serves as a facilitator of SG formation. However, the exon 7 skipping product, SMNDelta7, is largely retained in the nucleus and forms… CONTINUE READING
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