Survival from hypoxia in C. elegans by inactivation of aminoacyl-tRNA synthetases.

@article{Anderson2009SurvivalFH,
  title={Survival from hypoxia in C. elegans by inactivation of aminoacyl-tRNA synthetases.},
  author={Lori L. Anderson and Xianrong Mao and Barbara A. Scott and C. Michael Crowder},
  journal={Science},
  year={2009},
  volume={323 5914},
  pages={630-3}
}
Hypoxia is important in a wide range of biological processes, such as animal hibernation and cell survival, and is particularly relevant in many diseases. The sensitivity of cells and organisms to hypoxic injury varies widely, but the molecular basis for this variation is incompletely understood. Using forward genetic screens in Caenorhabditis elegans, we isolated a hypoxia-resistant reduction-of-function mutant of rrt-1 that encodes an arginyl-transfer RNA (tRNA) synthetase, an enzyme… CONTINUE READING