Survival distributions impact the power of randomized placebo-phase design and parallel groups randomized clinical trials.

@article{Abrahamyan2011SurvivalDI,
  title={Survival distributions impact the power of randomized placebo-phase design and parallel groups randomized clinical trials.},
  author={Lusine Abrahamyan and Chuan Silvia Li and Joseph Beyene and Andrew R. Willan and Brian Michael Feldman},
  journal={Journal of clinical epidemiology},
  year={2011},
  volume={64 3},
  pages={286-92}
}
OBJECTIVES The study evaluated the power of the randomized placebo-phase design (RPPD)-a new design of randomized clinical trials (RCTs), compared with the traditional parallel groups design, assuming various response time distributions. In the RPPD, at some point, all subjects receive the experimental therapy, and the exposure to placebo is for only a short fixed period of time. STUDY DESIGN AND SETTING For the study, an object-oriented simulation program was written in R. The power of the… CONTINUE READING