Survival and proliferative roles of erythropoietin beyond the erythroid lineage.

  title={Survival and proliferative roles of erythropoietin beyond the erythroid lineage.},
  author={Constance Tom Noguchi and Li Wang and Heather M Rogers and Ruifeng Teng and Yi Jia},
  journal={Expert reviews in molecular medicine},
Since the isolation and purification of erythropoietin (EPO) in 1977, the essential role of EPO for mature red blood cell production has been well established. The cloning of the EPO gene and production of recombinant human EPO led to the widespread use of EPO in treating patients with anaemia. However, the biological activity of EPO is not restricted to regulation of erythropoiesis. EPO receptor (EPOR) expression is also found in endothelial, brain, cardiovascular and other tissues, although… CONTINUE READING
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