Survival and function of intrastriatally grafted primary fibroblasts genetically modified to produce L-dopa.

@article{Fisher1991SurvivalAF,
  title={Survival and function of intrastriatally grafted primary fibroblasts genetically modified to produce L-dopa.},
  author={L. J. Fisher and H. A. Jinnah and Laxmikant Kal{\'e} and Gerald A. Higgins and Fred H. Gage},
  journal={Neuron},
  year={1991},
  volume={6 3},
  pages={371-80}
}
A combination of gene transfer and intracerebral grafting may provide a powerful technique for examining the role of discrete substances in the development or functioning of the brain. In the present study, primary fibroblasts obtained from a skin biopsy from inbred Fischer rats were used as donor cells for genetic modification and grafting. When grafted to the striatum of Fischer rats with a prior 6-hydroxydopamine lesion, primary fibroblasts containing a transgene for either tyrosine… CONTINUE READING

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