Survival and cellular immune functions in septic mice treated with growth hormone (GH) and insulin-like growth factor-I (IGF-I).

@article{Schmitz2008SurvivalAC,
  title={Survival and cellular immune functions in septic mice treated with growth hormone (GH) and insulin-like growth factor-I (IGF-I).},
  author={Daniel C. Schmitz and Phillip Kobbe and Sven Lendemanns and Klaus Wilsenack and Michael S. Exton and Manfred Schedlowski and Reiner Oberbeck},
  journal={Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society},
  year={2008},
  volume={18 3},
  pages={245-52}
}
OBJECTIVE GH was used to counteract the catabolic metabolism in critically ill patients until it was demonstrated that administration of GH was associated with an increased morbidity due to uncontrolled infections and sepsis. The immunomodulatory effect of GH and its main mediator IGF-I during systemic inflammation remain to be established. We therefore investigated the effect of GH and IGF-I on cellular immune functions in a murine model of sepsis. DESIGN Randomized animal study. Septic mice… CONTINUE READING