Survival and Toxicities of IMRT Based on the RTOG Protocols in Patients with Nasopharyngeal Carcinoma from the Endemic Regions of China

@article{Liang2017SurvivalAT,
  title={Survival and Toxicities of IMRT Based on the RTOG Protocols in Patients with Nasopharyngeal Carcinoma from the Endemic Regions of China},
  author={Shaobo Liang and Yan Wang and Xue‐feng Hu and Sha-sha He and Xing-Li Yang and Li-Zhi Liu and Chunyan Cui and Yong Chen and Li-Wu Fu},
  journal={Journal of Cancer},
  year={2017},
  volume={8},
  pages={3718 - 3724}
}
Background: This study evaluated the survival outcomes and toxicities of intensity-modulated radiation therapy (IMRT) based on the RTOG 0225/0615 RT protocols in patients with nasopharyngeal carcinoma (NPC) from a region of China where this tumor type is endemic. Methods: A total of 455 patients with non-metastatic, histologically-confirmed NPC were retrospectively reviewed. All patients were treated by IMRT using the RTOG 0225/0615 RT protocols; 91.1% (288/316) of patients with stage III-IVb… 

Figures and Tables from this paper

Induction chemotherapy plus concurrent chemoradiotherapy versus induction chemotherapy plus volumetric modulated arc therapy alone in the treatment of stage II-IVB nasopharyngeal carcinoma patients: a retrospective controlled study
TLDR
No significant difference in OS and PFS was observed between IC plus VMAT alone and IC/CCRT in the treatment of stage II-IVB NPC patients, however, more side effects were observed in the IC/ CCRT arm.
Influence of Tumor Necrosis on Treatment Sensitivity and Long-term Survival in Nasopharyngeal Carcinoma.
  • S. Liang, Lu-Si Chen, Xiangying Xu
  • Medicine
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • 2020
Analysis of intensity-modulated radiotherapy for patients with nasopharyngeal carcinoma
TLDR
Recurrence and metastasis mainly occur within 2 to 3 years after radiotherapy, and induction and concurrent chemotherapy improve the 5-year DSS of patients with locally advanced NPC.
Mixed-beam approach in locally advanced nasopharyngeal carcinoma: IMRT followed by proton therapy boost versus IMRT-only. Evaluation of toxicity and efficacy
TLDR
Sequential MB approach for LANPC patients provides a significantly lower acute toxicity profile compared to full course of IMRT, but a longer follow-up is required to achieve conclusive results.
Administration of nimotuzumab combined with cisplatin plus 5-fluorouracil as induction therapy improves treatment response and tolerance in patients with locally advanced nasopharyngeal carcinoma receiving concurrent radiochemotherapy: a multicenter randomized controlled study
TLDR
For locally advanced NPC patients receiving follow- up cisplatin and IMRT, nimotuzumab/PF for induction therapy has better lymph node response rate and milder adverse reactions than the DPF regimen, and the patients have better tolerance in subsequent concurrent radiotherapy and chemotherapy; however, long-term efficacy needs further follow-up evaluation.
Local definitive intensity-modulated radiation therapy recommended for patients initially diagnosed with nasopharyngeal carcinoma with distant metastasis after an effective systemic chemotherapy *
TLDR
It is suggested that local definitive IMRT should be recommended in patients initially diagnosed with NPC with distant metastasis after an effective systemic chemotherapy, which may possibly prolong their survival time and potentially treat the disease.
Radiation-induced acute injury of intensity-modulated radiotherapy versus three-dimensional conformal radiotherapy in induction chemotherapy followed by concurrent chemoradiotherapy for locoregionally advanced nasopharyngeal carcinoma: a prospective cohort study
TLDR
In a combined regimen of IC followed by CCRT for the treatment of LANPC, IMRT seems to be an aggressive technique with a trend towards increased gastrointestinal and hematological toxicities, but decreased bone marrow toxicity than those treated with 3D-CRT.
Comparison of three-dimensional conformal radiotherapy with intensity modulated radiotherapy in the treatment of locally advanced non-small cell lung cancer: retrospective analysis of 250 cases
TLDR
Compared with three-dimensional conformation radiotherapy, intensity modulated radiotherapy has a better therapeutic effect on locally advanced non-small cell lung cancer, and the incidence of adverse reactions and recurrence is relatively lower.
...
1
2
...

References

SHOWING 1-10 OF 39 REFERENCES
Long-term outcomes of intensity-modulated radiotherapy for 868 patients with nasopharyngeal carcinoma: an analysis of survival and treatment toxicities.
  • Xue-ming Sun, S. Su, T. Lu
  • Medicine
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • 2014
Effectiveness and Toxicities of Intensity-Modulated Radiation Therapy for Patients with T4 Nasopharyngeal Carcinoma
TLDR
IMRT provides excellent local-regional control for T4 NPC andDistant metastasis remains the major cause of treatment failure and further explorations of the sequence and regimen of systemic therapy are needed in the future.
Induction Chemotherapy Improved Long-term Outcomes of Patients with Locoregionally Advanced Nasopharyngeal Carcinoma: A Propensity Matched Analysis of 5-year Survival Outcomes in the Era of Intensity-modulated Radiotherapy
TLDR
IC is an effective treatment modality for patients with stage T1-2N2-3 and T3-4N1-3 NPC, and the incorporation of IC with standard CCRT could achieve the best therapeutic gain.
Analysis of late toxicity in nasopharyngeal carcinoma patients treated with intensity modulated radiation therapy
TLDR
The late injuries in most NPC patients who had long-term survivals after IMRT are alleviated, and xerostomia decreased gradually over time and the change in the incisor distance stabilised by 1 year after RT; while hearing loss, nervous system injuries increased over time after RT.
Late toxicities after intensity-modulated radiotherapy for nasopharyngeal carcinoma: patient and treatment-related risk factors
TLDR
With the application of IMRT, the incidence of radiation-related complications has been reduced except for TLI, and the significant factors affecting the risk of TLI included T category, chemotherapy and Dmax.
The additional value of chemotherapy to radiotherapy in locally advanced nasopharyngeal carcinoma: a meta-analysis of the published literature.
TLDR
Concomitant chemotherapy in addition to radiation is probably the most effective way to improve OS in NPC, according to the results of this meta-analysis.
Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup study 0099.
  • M. al-Sarraf, M. Leblanc, J. Ensley
  • Medicine, Biology
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 1998
TLDR
It is concluded that chemoradiotherapy is superior to radiotherapy alone for patients with advanced nasopharyngeal cancers with respect to PFS and overall survival.
Is maximum primary tumor diameter still a prognostic factor in patients with nasopharyngeal carcinoma treated using intensity-modulated radiotherapy?
TLDR
MPTD was an independent prognostic factor in patients with NPC treated using IMRT, and significantly improved the prognostic value of the current T classification criteria for NPC.
...
1
2
3
4
...