Survival and Evolution of a Large Multidrug Resistance Plasmid in New Clinical Bacterial Hosts

Abstract

Large conjugative plasmids are important drivers of bacterial evolution and contribute significantly to the dissemination of antibiotic resistance. Although plasmid borne multidrug resistance is recognized as one of the main challenges in modern medicine, the adaptive forces shaping the evolution of these plasmids within pathogenic hosts are poorly… (More)

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