Survival and Death Strategies in Glioma Cells: Autophagy, Senescence and Apoptosis Triggered by a Single Type of Temozolomide-Induced DNA Damage

@inproceedings{Knizhnik2013SurvivalAD,
  title={Survival and Death Strategies in Glioma Cells: Autophagy, Senescence and Apoptosis Triggered by a Single Type of Temozolomide-Induced DNA Damage},
  author={Anna V. Knizhnik and Wynand Paul Roos and T. Nikolova and Steve Quir{\'o}s and Karl-Heinz Tomaszowski and Markus Christmann and Bernd Kaina},
  booktitle={PloS one},
  year={2013}
}
Apoptosis, autophagy, necrosis and cellular senescence are key responses of cells that were exposed to genotoxicants. The types of DNA damage triggering these responses and their interrelationship are largely unknown. Here we studied these responses in glioma cells treated with the methylating agent temozolomide (TMZ), which is a first-line chemotherapeutic for this malignancy. We show that upon TMZ treatment cells undergo autophagy, senescence and apoptosis in a specific time-dependent manner… CONTINUE READING
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