Survival and B-cell function of mouse pancreatic islets maintained in culture after concomitant exposure to streptozotocin and nicotinamide.

@article{Strandell1989SurvivalAB,
  title={Survival and B-cell function of mouse pancreatic islets maintained in culture after concomitant exposure to streptozotocin and nicotinamide.},
  author={Eva Strandell and Decio L. Eizirik and S. K. Adler Sandler},
  journal={Experimental and clinical endocrinology},
  year={1989},
  volume={93 2-3},
  pages={
          219-24
        }
}
It has recently been suggested from experiments performed on isolated pancreatic islets in vitro, that streptozotocin (SZ) may exert a progressive damage to the islet B-cells. It may be that this damaging effect is not dependent on the acute activation of the enzyme poly(ADP-ribose) synthetase, and a subsequent depletion of the islet NAD content. In the present study we have exposed mouse pancreatic islets in vitro to 2.2 mM SZ for 30 min at 37 degrees C, in the presence or absence of 10 mM… CONTINUE READING
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