Surveying Saccharomyces genomes to identify functional elements by comparative DNA sequence analysis.

@article{Cliften2001SurveyingSG,
  title={Surveying Saccharomyces genomes to identify functional elements by comparative DNA sequence analysis.},
  author={Paul F. Cliften and LaDeana W. Hillier and Lucinda Fulton and Tina Graves and Tracie L. Miner and Warren Gish and Robert H. Waterston and Mark Johnston},
  journal={Genome research},
  year={2001},
  volume={11 7},
  pages={1175-86}
}
Comparative sequence analysis has facilitated the discovery of protein coding genes and important functional sequences within proteins, but has been less useful for identifying functional sequence elements in nonprotein-coding DNA because the relatively rapid rate of change of nonprotein-coding sequences and the relative simplicity of non-coding regulatory sequence elements necessitates the comparison of sequences of relatively closely related species. We tested the use of comparative DNA… CONTINUE READING

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