Survey of the translation shifts in hepatocellular carcinoma with ribosome profiling

  title={Survey of the translation shifts in hepatocellular carcinoma with ribosome profiling},
  author={Qin Zou and Zhengtao Xiao and Rongyao Huang and Xin Wang and Xun Wang and Haitao Zhao and Xuerui Yang},
  pages={4141 - 4155}
  • Qin Zou, Zhengtao Xiao, +4 authors Xuerui Yang
  • Published 2019
  • Biology, Medicine
  • Theranostics
Despite the critical position of translation in the multilevel gene expression regulation program, high-resolution and genome-wide view of the landscape of RNA translation in solid tumors is still limited. Methods: With a ribosome profiling procedure optimized for solid tissue samples, we profiled the translatomes of liver tumors and their adjacent noncancerous normal liver tissues from 10 patients with hepatocellular carcinoma (HCC). A set of bioinformatics tools was then applied to these data… Expand
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