Surveillance of antigen-presenting cells by CD4+ CD25+ regulatory T cells in autoimmunity: immunopathogenesis and therapeutic implications.

@article{Andr2009SurveillanceOA,
  title={Surveillance of antigen-presenting cells by CD4+ CD25+ regulatory T cells in autoimmunity: immunopathogenesis and therapeutic implications.},
  author={S{\'e}bastien Andr{\'e} and David F. Tough and S{\'e}bastien Lacroix-Desmazes and Srini V Kaveri and Jagadeesh Bayry},
  journal={The American journal of pathology},
  year={2009},
  volume={174 5},
  pages={1575-87}
}
CD4+CD25+ regulatory T cells (Tregs) play a critical role in preventing immune aggression. One way in which Tregs exert immune surveillance activities is by modifying the function of antigen presenting cells (APCs) such as dendritic cells, macrophages, and B cells. Tregs can induce apoptosis of APCs or inhibit their activation and function, thereby regulating subsequent innate and adaptive immune responses. These actions of Tregs are mediated by both soluble factors (interleukin [IL]-10… CONTINUE READING
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