Surveillance for early detection of aggressive parathyroid disease: carcinoma and atypical adenoma in familial isolated hyperparathyroidism associated with a germline HRPT2 mutation.

@article{Kelly2006SurveillanceFE,
  title={Surveillance for early detection of aggressive parathyroid disease: carcinoma and atypical adenoma in familial isolated hyperparathyroidism associated with a germline HRPT2 mutation.},
  author={Thomas G Kelly and Trisha M Shattuck and Miguel Reyes-M{\'u}gica and Andrew Francis Stewart and William F. Simonds and Robert D Udelsman and Andrew O. Arnold and Thomas O. Carpenter},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2006},
  volume={21 10},
  pages={1666-71}
}
UNLABELLED Familial hyperparathyroid syndromes involving mutations of HRPT2 (also CDC73), a tumor suppressor, are important to identify because the relatively high incidence of parathyroid malignancy associated with such mutations warrants a specific surveillance strategy. However, there is a dearth of reports describing experience with surveillance and early detection informed by genetic insight into this disorder. INTRODUCTION Familial isolated hyperparathyroidism (FIHP) is a rare cause of… CONTINUE READING

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