Surrogate threshold effect: an alternative measure for meta-analytic surrogate endpoint validation.

@article{Burzykowski2005SurrogateTE,
  title={Surrogate threshold effect: an alternative measure for meta-analytic surrogate endpoint validation.},
  author={Tomasz Burzykowski and M. Buyse},
  journal={Pharmaceutical statistics},
  year={2005},
  volume={5 3},
  pages={
          173-86
        }
}
In many therapeutic areas, the identification and validation of surrogate endpoints is of prime interest to reduce the duration and/or size of clinical trials. Buyse et al. [Biostatistics 2000; 1:49-67] proposed a meta-analytic approach to the validation. In this approach, the validity of a surrogate is quantified by the coefficient of determination Rtrial2 obtained from a model, which allows for prediction of the treatment effect on the endpoint of interest ('true' endpoint) from the effect on… CONTINUE READING
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