The purpose of this study was to describe a domain of spiritual coping known as “surrender,” as experienced among women diagnosed with breast cancer who participated in Psycho-Spiritual Integrative Therapy (PSIT). Surrender is a concept similar to active acceptance, which has been studied extensively, but surrender in the context of spiritual supportive care has received little attention. After participating in PSIT, which includes exercises in surrender, 23 participants completed an open-ended questionnaire about their experiences of surrender. Twelve women whose responses were most complete and expressive were selected to be analyzed for this study. A thematic analysis was conducted to better understand how surrender experiences may contribute to supportive care. Four distinct themes were identified: experience of surrender, facilitation of surrender, inhibition of surrender, and ease and completeness of surrender. Although the manifestations of surrender varied, women were consistent in describing these experiences positively. These findings build upon previous evidence that spirituality, optimism, and active acceptance have a positive impact on well-being in cancer patients. The findings provide insight into the usefulness of PSIT for women with breast cancer and inform future research on the intervention.